The Impact of International Bioethics on the 'Sanctity of Life Ethics', and the Ability of OB Gyn's to Practice According to Conscience. pg.6

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E. Endnotes: (con't)

47  The term "pre–embryo" has been explicitly rejected by the International Nomina Embryologica, as noted earlier by one of its committee members in his text: "The ill–defined and inaccurate term pre–embryo, which includes the embryonic disc, is said either to end with the appearance of the primitive streak or ... to include neurulation. The term is not used in this book." [O'Rahilly and Muller (1994), p. 55] Unlike some other scientific fields, the field of human embryology is professionally required to follow the standard "Carnegie Stages", terminology and definitions as determined by this international committee composed of expert human embryologists from around the world. The "arbitrary" use of terms and definitions are not professionally accepted. [Back]

48 Richard A. McCormick, S. J., "To Save or Let Die," Journal of the American Medical Association (1974), 229:172–176. See also, John C. Fletcher, "Abortion, Euthanasia and Care of the Defective Newborn", New England Journal of Medicine (1975); 292:75–79; H. Tristram Engelhardt, Jr., "Ethical Issues in Aiding the Death of Young Children," in Martin Kohl (ed.), Beneficent Euthanasia (Buffalo, N.Y.: Prometheus Books, 1975), pp. 180–192; John Robertson and Norman Fost, "Passive Euthanasia of Defective Newborn Infants," Journal of Pediatrics 88 (1976), 88:883–192; John Robertson, "Involuntary Euthanasia of Defective Newborns: A Legal Analysis," Stanford Law Review (1975), 27:213–269; Albert R. Jonsen and Michael J. Garland (eds.), Ethics of Newborn Intensive Care (Berkeley: Institute for Government Studies, 1976), pp. 33 and 190; Albert Jonsen, William Tooley, Roderick Phibbs, and Michael Garland, "Critical Issues in Newborn Intensive Care: A Conference Report and Policy Proposal," Pediatrics (1975), 55:756–768; Barbara Culliton, "Intensive Care for Newborns: Are There Times to Pull the Plug?", Science (1975), 188:133–134; Paul Ramsey, "An Ingathering of Other Reasons for Neonatal Infanticide," in Ethics at the Edges of Life: Medical and Legal Intersections (New Haven: Yale University Press, 1978), pp., 228–267, 250; Darrel W. Amundsen, "Medicine and the Birth of Defective Children: Approaches of the Ancient World," in Richard M. McMillan, H. Tristram Engelhardt, Jr., and Stuart F. Spicker (eds.), Euthanasia and the Newborn: Conflicts Regarding Saving Lives (Dordrecht/Boston: D. Reidel Publishing Company, 1987), pp. 3–22; Maria W. Piers, Infanticide (New York: Norton, 1978); Clement A. Smith, "Neonatal Medicine and Quality of Life: An Historical Perspective", in Jonsen and Garland (eds.), Ethics of Newborn Intensive Care, p. 33; Alexander Schaffere, Diseases of the Newborn (Philadelphia: Saunders, 1960); William Silverman, "The Lesson of Retrolental Fibroplasia," Scientific American (1977), 236:100–107; Paul A. Freund, "Mongoloids and 'Mercy Killing'" in Reiser et al, Ethics in Medicine, pp. 536–538; James M. Gustafson, "Mongolism, Parental Desires and the Right to Live," Perspectives in Biology and Medicine (1973), 16:4:529–557; Raymond S. Duff and A. G. M. Campbell "Moral and Ethical Dilemmas in the Special–Care Nursery," New England Journal of Medicine (1973), 289:890–984; President's Commission on Ethical Problems in Medicine and Biomedical and Behavioral Research, Deciding to "Forego Life-Sustaining Treatment: A Report on the Ethical and Legal Issues in Treatment Decisions (Washington, D.C.: U.S. Government Printing Office, 1982), Chapter 6; Cindy Bouillon–Jensen, "Infanticide," in Warren T. Reich (ed.), Encyclopedia of Bioethics (2nd ed.) (New York: Simon and Schuster Macmillan, 1995), pp. 1200–1205; Martin S. Pernick, The Black Stork: Eugenics and the Death of "Defective" Babies in American Medicine and Motion Pictures (New York: Oxford University Press, 1996) [Back]

49  See discussions on the impact of the work of Richard McCormick on the development of bioethics in the current NBAC commissioned paper by John C. Fletcher, "Deliberating Incrementally on Human Pluripotential Stem Cell Research", [], Sept. 1999, p. E-11 and several others; also in Jonsen, pp. 52-56, 100, 106, 154-155, 247, 259, 291, 293, 310–311. [Back]

50  Andre E. Hellegers, "Fetal Development", Theological Studies (1970), 31:3–9; Hellegers, "Fetal Development", in Thomas A. Mappes and Jane S. Zembatty (eds.), Biomedical Ethics (New York: Macmillan, 1981). [Back]

51  See, e.g., Richard McCormick, S. J., "Who or What is the Preembryo?", Kennedy Institute of Ethics Journal 1:1 (1991). In this paper McCormick draws heavily on the work of frog embryologist Clifford Grobstein, as well as from "an unpublished study of a research group of the Catholic Health Association entitled 'The Status and Use of the Human Preembryo' ...". (p. 14). The influence of the McCormick/Grobstein term "pre–embryo" was (and still is) widespread even among Catholic scholars. In addition to the works of McCormick and Grobstein, see acceptance of the term "pre–embryo" also in the work of other Catholic writers: Andre E. Hellegers, "Fetal Development," in Thomas A. Mappes and Jane S. Zembatty (eds.), Biomedical Ethics, (New York: Macmillan, 1981); Hellegers, "Fetal Development", Theological Studies (1970), 31:3–9; Charles E. Curran, "Abortion: Contemporary Debate in Philosophical and Religious Ethics", in W. T. Reich (ed.), Encyclopedia of Bioethics 1 (London: The Free Press, 1978), pp. 17–26; Kevin Wildes, "Book Review: Human Life: Its Beginning and Development" (L'Harmattan, Paris: International Federation of Catholic Universities, 1988); Carlos Bedate and Robert Cefalo, "The Zygote: To Be or Not Be a Person", Journal of Medicine and Philosophy (1989), 14:6:641; Robert C. Cefalo, "Book Review: Embryo Experimentation, Peter Singer et al (eds.); 'Eggs, Embryos and Ethics'", Hastings Center Report (1991), 21:5:41; Mario Moussa and Thomas A. Shannon, "The Search for the New Pineal Gland: Brain Life and Personhood", The Hastings Center Report (1992), 22:3:30–37; Carol Tauer, The Moral Status of the Prenatal Human (Doctoral Dissertation in Philosophy; Kennedy Institute of Ethics, Georgetown University, Washington, D.C.: Georgetown University, 1981) (Sister Tauer's dissertation mentor was Richard McCormick; she later went on to become the ethics co–chair of the NIH Human Embryo Research Panel 1994); C. Tauer, "The Tradition of Probabilism and the Moral Status of the Early Embryo", in Patricia B. Jung and Thomas A. Shannon, Abortion and Catholicism (New York: Crossroad, 1988), pp. 54–84; Lisa S. Cahill, "Abortion, Autonomy, and Community", in Jung and Shannon, Abortion and Catholicism (1988), pp. 85–98; Joseph F. Donceel, "A Liberal Catholic's View", in Jung and Shannon, Abortion and Catholicism (1988), pp. 48-53; H. Tristram Engelhardt, The Foundations of Bioethics (New York: Oxford University Press, 1985), p. 111; William A. Wallace, "Nature and Human Nature as the Norm in Medical Ethics", in Edmund D. Pellegrino, John P. Langan and John Collins Harvey (eds.), Catholic Perspectives on Medical Morals (Dordrecht: Kluwer Academic Publishing, 1989), pp. 23–53; Norman Ford, When Did I Begin? (New York: Cambridge University Press, 1988), p. 298; Antoine Suarez, "Hydatidiform Moles and Teratomas Confirm the Human Identity of the Preimplantation Embryo", Journal of Medicine and Philosophy (1990), 15:627–635; Thomas J. Bole, III, "Metaphysical Accounts of the Zygote as a Person and the Veto Power of Facts", Journal of Medicine and Philosophy (1989), 14:647–653; Bole, "Zygotes, Souls, Substances, and Persons", Journal of Medicine and Philosophy (1990), 15:637–652. [Back]

52  See Richard McCormick's testimony in The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research; Report and Recommendations; Research on the Fetus; U.S. Department of Health, Education and Welfare, 1975, pp. 34–35; McCormick, How Brave a New World? (Washington, D.C.: Georgetown University Press), p. 76; McCormick, "Proxy Consent in the Experimentation Situation", Perspectives in Biology and Medicine (1974), 18:2–20. [Back]

53  See Paul Ramsey's testimony in The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research; Report and Recommendations; Research on the Fetus; U.S. Department of Health, Education and Welfare, 1975, pp. 35–36. [Back]

54  For further analysis of the use of the erroneous term "pre–embryo" in the work of both McCormick and Grobstein (and others) see: Dianne N. Irving, A Philosophical and Scientific Analysis of the Nature of the Early Human Embryo (Doctoral Dissertation; Department of Philosophy, Georgetown University, Washington, D.C.; University Microfilms, 1991), esp. Chapter 3 (the Dissertation includes an analysis of the works of 28 other bioethicists who also argue for "delayed personhood" based on different "biological marker events" throughout prenatal development — and beyond. Most of these bioethicists were referenced in the NIH Human Embryo Research Panel meetings and report). See also: Irving, "Science, Philosophy and Expertise: An Evaluation of the Arguments on 'Personhood'", Linacre Quarterly (Feb. 1993), 60(1):18–46; Irving, "When Does a Human Being Begin? 'Scientific' Myths and Scientific Facts", International Journal of Sociology and Social Policy (1999), 19:3/4:22–47; Ward C. Kischer and Dianne N. Irving, The Human Development Hoax: Time To Tell The Truth! (1997, distributed by American Life League).
The use of the term "pre–embryo" has been quite widespread for decades — nationally and internationally. In addition to the Catholic scholars who accepted the use of the term "pre–embryo" as noted above, a partial list of secular bioethics writers who also accepted the use of the term in these debates includes: Paul Ramsey, "Reference Points in Deciding About Abortion" in J. T. Noonan (ed.), The Morality of Abortion (Cambridge, MA: Harvard University Press, 1970), pp. 60–100, esp. p. 75; John Robertson, "Extracorporeal Embryos and the Abortion Debate", Journal of Contemporary Health Law and Policy (1986), 2;53;53–70; Robertson, "Symbolic Issues in Embryo Research", The Hastings Center Report (1995, Jan./Feb.), 37–38; Robertson, "The Case of the Switched Embryos", The Hastings Center Report (1995), 25:6:13–24; Howard W. Jones, "And Just What is a Preembryo?", Fertility and Sterility 52:189–91; Jones and C. Schroder, "The Process of Human Fertilization: Implications for Moral Status", Fertility and Sterility (August 1987), 48:2:192; Clifford Grobstein, "The Early Development of Human Embryos", Journal of Medicine and Philosophy (1985), 10:213–236; also, Science and the Unborn (New York: Basic Books, 1988), p. 61; Michael Tooley, "Abortion and Infanticide", in The Rights and Wrongs of Abortion, M. Cohen et al (eds.) (New Jersey: Princeton University Press, 1974), pp. 59 and 64; Peter Singer and Helga Kuhse, "The Ethics of Embryo Research", Law, Medicine and Health Care (1987),14:13–14; Kuhse and Singer, "For Sometimes Letting — and Helping — Die", Law, Medicine and Health Care (1986), 3:40:149–153; Kuhse and Singer, Should The Baby Live? The Problem of Handicapped Infants (Oxford University Press, 1985), p.138; Singer, "Taking Life: Abortion", in Practical Ethics (London: Cambridge University Press, 1981), pp. 122–123; Peter Singer, Helga Kuhse, Stephen Buckle, Karen Dawson, Pascal Kasimba (eds.), Embryo Experimentation (New York: Cambridge University Press, 1990); R. M. Hare, "When Does Potentiality Count? A Comment on Lockwood," Bioethics (1988), 2:3:214; Michael Lockwood, "When Does Life Begin?", in Michael Lockwood (ed.), Moral Dilemma's in Modern Medicine (New York: Oxford University Press, 1985), p. 10; Hans–Martin Sass, "Brain Life and Brain Death: A Proposal for Normative Agreement," Journal of Medicine and Philosophy (1989), 14:45–59; Michael Lockwood, "Warnock Versus Powell (and Harradine): When Does Potentiality Count?" Bioethics (1988), 2:3:187-213.
See also the use of the term "pre-embryo" in many national and international documents (a small sample): Ethics Advisory Board (1979) Report and Conclusions: HEW Support of Research Involving Human In Vitro Fertilization and Embryo Transfer, Washington, D.C.: United States Department of Health, Education and Welfare, p. 101; National Institutes of Health Human Embryo Research Panel Meetings (Washington, D.C.: NIH, 1994), Feb. 2 meeting, pp. 27, 31, 50–80, 85–87, 104–106; in the Feb. 3, 1994 meeting, pp. 6–55; April 11 meeting, pp. 23–41, 9–22. See also, Dame Mary Warnock, Report of the Committee of Inquiry into Human Fertilization and Embryology, (London: Her Majesty's Stationary Office, 1984), pp. 27 and 63; Commonwealth of Australia, Select Senate Committee on the Human Embryo Experimentation Bill, (Canberra, Australia: Official Hansard Report, Commonwealth Government Printer, 1986); Parliamentary Assembly of the Council of Europe, On the Use of Human Embryos and Foetuses for Diagnostic, Therapeutic, Scientific, Industrial and Commercial Purposes, Recommendation 1046, 1986; and On the Use of Human Embryos and Foetuses in Scientific Research, Recommendation 1000, 1989; Ethics Committee of the American Fertility Society (AFS), "Ethical Considerations of the New Reproductive Technologies", Fertility and Sterility (1986), 46:27S. See also Jonsen (1998), esp. Chapters 4 and 12. [Back]

55  In historical terms, this is referred to as the "chorismos" (or, "separation") problem in philosophy, originated by Plato in his famous "Theory of Forms". For discussions of Plato's quite extensive chorismos problems, see: Etienne Gilson, Being and Some Philosophers (Toronto: Pontifical Institute of Mediaeval Studies, 1949); Frederick Copleston, A History of Philosophy (New York: Image Books, 1993), Vol. 1, pp. 167 ff; Leonard J. Eslick, "The Material Substrate in Plato", in Ernan McMullin (ed.), The Concept of Matter in Greek and Medieval Philosophy (Indiana: University of Notre Dame Press, 1963); Frederick Wilhelmsen, Man's Knowledge of Reality (New Jersey: Prentice–Hall, Inc., 1956), esp. Chaps. 2 and 3. Descartes tried to give an explanation of interaction, but miserably failed and was literally laughed out of the academy. See Descartes' efforts in his Meditations (especially his Sixth Meditation), in J. Cottingham, R. Stoothoff, D. Murdoch (trans.), The Philosophical Writings of Descartes (Cambridge: Cambridge University Press, 1989). See also, Frederick Copleston, A History of Philosophy (New York: Image Books/Doubleday, 1994), Vol. 4, pp. 120 ff; Paul Edwards, The Encyclopedia of Philosophy (New York: Macmillan Publishing Co., Inc. and The Free Press, 1972), Vols. 1 and 2, pp. 353-354. [Back]

56  For extensive philosophical and scientific analyses of these positions, see references in note 54, supra. [Back]

57  The Church has consistently taught that to intentionally and directly kill an innocent human being at any stage of development is inherently evil — regardless of the "personhood" status. E.g., Declaration on Procured Abortion: "In the course of history, the Fathers of the Church, her Pastors and her Doctors have taught the same doctrine —- the various opinions on the infusion of the spiritual soul did not introduce any doubt about the illicitness of abortion ... This condemnation was in fact unanimous [II.6]. ... The tradition of the Church has always held that human life must be protected and favored from the beginning, just as at the various stages of its development [II.6]. E.g., Donum Vitae: "From the moment of conception, the life of every human being is to be respected in an absolute way ... [Intro. 5]. ... At the second Vatican Council, the Church for her part presented once again to modern man her constant and certain doctrine according to which: 'Life, once conceived, must be protected with the utmost care; abortion and infanticide are abominable crimes.' More recently, the Charter of the Rights of the Family, published by the Holy See, confirmed that 'human life must be absolutely respected and protected from the moment of conception.' ... The Congregation recalls the teachings found in the Declaration on Procured Abortion: 'From the time that the ovum is fertilized, a new life is begun which is neither that of the father nor of the mother; it is rather the life of a new human being with his own growth. It would never be made human if it were not human already. To this perpetual evidence ... modern genetic science brings valuable confirmation.' ... This teaching remains valid and is further confirmed ... by recent findings of human biological science which recognize that in the zygote resulting from fertilization the biological identity of a new human individual is already constituted. ... Certainly no experimental datum can be in itself sufficient to bring us to the recognition of a spiritual soul; nevertheless, the conclusions of science regarding the human embryo provide a valuable indication for discerning by the use of reason a personal presence at the moment of this first appearance of a human life; how could a human individual not be a human person? ... [S]ince the embryo must be treated as a person, it must also be defended in its integrity, tended and cared for, to the extent possible, in the same way as any other human being as far as medical assistance is concerned." [I.1] [Back]

58  The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research; Report and Recommendations; Research on the Fetus; U.S. Department of Health, Education and Welfare, 1975; "Dissenting Statement of Commissioner David W. Louisell" (p. 77-82). [Back]

59  See David S. Oderberg, Moral Theory: A Non–Consequentialist Approach (Oxford: Blackwell Publishers Inc., 2000), pp. 167–168. See also definition of "preference utilitarianism" at: [Back]

60  Ibid., Oderberg (2000), p. 174. [Back]

61  Jonathan Glover, Causing Death and Saving Lives: The Moral Problems of Abortion, Infanticide, Suicide, Euthanasia, Capital Punishment, War, and Other Life–or–Death Choices (New York: Penguin Books, 1977). [Back]

62  See, e.g., Jonathan Glover, What Sort of People Should there Be? (New York: Penguin Books, 1984): "[T]he central issue is about changing human nature. I want to argue for greater willingness to consider policies that would do this, so it seems important to meet conservatism about human nature on its strongest ground (p. 16). ... [O]n the way we will be forced to do some fresh thinking about what autonomy is, and why we value it. ... Changes in society and in human nature can be expected to involve changes in values (p. 19). ... There is a widespread view that any project for the genetic improvement of the human race ought to be ruled out: that there are fundamental objections of principle. The aim of this discussion is to sort out some of the main objections. It will be argued that [such] resistance is based on a complex of different values and reasons, none of which is, when examined, adequate to rule out in principle this use of genetic engineering." (p. 25). Glover also considers human cloning, and human/animal cross–breeding as well. [Back]

63  Op. cit., Glover, Causing Death and Saving Lives (1977), pp. 50–59. [Back]

64  R. M. Hare, "When Does Potentiality Count? A Comment on Lockwood", Bioethics (1988), 2:3:214. [Back]

65  Peter Singer, Practical Ethics (London: Cambridge University Press, 1985), pp. 118, 123; see also, Helga Kuhse and Peter Singer, "For Sometimes Letting — and Helping — Die," Law, Medicine and Health Care (1986), 3:4:149–153; Kuhse and Singer, Should the Baby Live? The Problem of Handicapped Infants (Oxford: Oxford University Press, 1985), p. 138. [Back]

66  R. G. Frey, "The Ethics of the Search For Benefits: Animal Experimentation in Medicine", in Raanan Gillon (ed.), Principles of Health Care Ethics (New York: John Wiley & Sons, 1994), pp. 1067–1075. Frey is now a Senior Scholar at The Hastings Center. [Back]

67  Peter Singer, "Heavy Petting", []. [Back]

68  Peter Suber, "Against the Sanctity of Life" [Philosophy Dept., Earlham College, Indiana — Quaker] ( [Back]

69  Ibid., Suber: "But in general the QL ["quality of life"] view is easy to state. It is the view that the value of a life varies with its quality. That value might be absolute, infinite, or maximum, but only if circumstances permitted it; other circumstances can reduce that value. The value of a life is contingent. It follows directly that not all lives have equal value. Hence, QL denies both the equality condition and the unqualified ultimity condition of SL ["sanctity of life" view]. ... The positive approach requires that a life possess some positive features or set of features to be worth living, such as dignity, autonomy, and rationality, while the negative approach requires that a life simply lack certain negative features to be worth living, such as extreme pain, hopeless deterioration, and irreversible incapacity to give or withhold consent. The positions can be combined to hold that a life is worth living only if certain positive features are present and certain negative features absent." [Back]

70  Darryl R. J. Macer, Shaping Genes: Ethics, Law and Science of Using New Genetic Technology in Medicine and Agriculture, (Eubios Ethics Institute, Japan, 1990), Chapter on "Status of the Embryo", on–line at:]

71  Norman Ford, When Did I Begin? (New York: Cambridge University Press, 1988). [Back]

72  Ibid., Macer (1990): "The current attitude of society is that there is a steady and gradual unfolding of life and a gradual assumption of rights by the embryo. ... From the reasoned argument based on biological knowledge, and ethical principles it is possible to draw different lines in the status of the embryo at fertilisation, implantation, formation of the cerebral cortex, and viability. An early embryo is a body in preparation at least, and the likelihood of homicide increases with the age of the individual. ... There are sufficient doubts over the commencement of human personhood until the cerebral cortex begins to function, not to consider the embryo a person until at least 8 weeks and possibly up to 24 weeks." [Back]

73  Ibid., Macer (1990): "When the earth is crowded, and so many resources used, we should not overfill it. There is a limit to the land. We need to control the desire to have many children, and what is more important allow choice to those who want birth control, and use reason and common sense, and the techniques that we have been given in our technology to practise sensible birth control." (In Chapter on "Human Reproduction"; [Back]

74  Ibid., Macer (1990): "One of the aims of eugenics today is the "application of societal measures at improving physical and mental attributes of future generations" (Eugenics Society 1988). This is not in itself dissimilar from most peoples' attitude. It is held by many that it is in the interests of the state to reduce the incidence of genetic disease (Mason & McCall-Smith 1983)." (Chapter on "Selective Breeding"; ... In favour of genetic engineering is utilitarian thinking. Although there will be risks for individuals the goal of the application of these techniques will be to aid human beings, in reducing genetic disease and its affects, and possibly improving the human race (Brody 1981). We are rational beings and we should take advantage of the chances used to apply our rationality to the control of something so important as the generation of children, and to agriculture and environmental modification. We have allowed many people that have genetic disease to live, and so have exposed the human race to genetic decay, for example diseases like diabetes are increasing. This is seen as a bad affect on the human gene pool, and something to counter." (Chapter on "Genetic Engineering"; [Back]

75  H. Tristram Engelhardt, "Viability and the Use of the Fetus", in Tom L. Beauchamp and Terry P. Pinkard (eds.), Ethics and Public Policy: An Introduction to Ethics (Englewood Cliffs, NJ: Prentice–Hall, Inc., 1983, pp. 299–230; reprinted from W. B. Bondeson, H. Tristram Engelhardt, Jr., S. F. Spicker, and Daniel Winship (eds.), Abortion and the Status of the Fetus (Dordrecht, Holland: Reidel Publishing Company, 1982).
See also Engelhardt's further reflections on the "personhood" of human pre-born and young children: "... It is for these reasons that the value of zygotes, embryos, and fetuses is to be primarily understood in terms of the values they have for actual persons. Zygotes, fetuses, and embryos do not have the rich inward life of adult mammals. ... However, one must remember that the sentience of a zygote, embryo, or fetus is much less than that of an adult mammal. One might even develop a suggestion of the natural theologian Charles Hartshorne so as to argue that from the perspective of the Deity the intrinsic value of a human fetus will be less than that of an adult normal member of some other mammalian species. (pp. 112–113). ... One also owns what one produces. One might think here of both animals and young children. Insofar as they are the products of the ingenuity or energies of persons, they can be possessions. There are, however, special obligations to animals by virtue of the morality of beneficence that do not exist with regard to things. Such considerations, as well as the fact that young children will become persons, limit the extent to which parents have ownership rights over their young children. However these limits will be very weak with regard to ownership rights in human zygotes, embryos, and fetuses that will not be allowed to develop into persons, or with regard to lower vertebrates, where there is very little sentience. For example, it would appear very plausible that plants, microbes, and human zygotes can be fashioned as products, and be bought and sold as if they were simply things. In contrast, strong claims of ownership would cease, as children become persons and sui juris, self-possessing. This latter moral issue also arises with regard to normal adult non-human higher primates. It is much more plausible to suspect that higher non-human primates are in possession of themselves than to suspect that such is the case with even one-year-old human infants. At the point that an entity becomes self-conscious, the morality of mutual respect would alienate the property rights of the parents over the children or other animals (129–130). ... These reflections can be encapsulated in what one may term the principle of ownership. This principle will be central to understanding the roles of public and private funding in health care, as well as the rights of physicians to exempt themselves from the constraints of national health services. Owning private property, insofar as such private ownership exists, will always permit patients merely to buy around the established system. So, too, having the right to own one's talents will permit physicians to sell around the constraints of the system. This can be tendentiously summarized as the basic right of persons to the black market." (emphases added) Engelhardt, The Foundations of Bioethics (New York: Oxford University Press, 1986), pp. 133–134. [Back]

76  See, Victoria Button, "Control Gene Pool, Says Ethicist", The Age [], October 13, 2000. [Back]

77  Quoting from Dr. Harold Varmus' Senate testimony: "Totipotent stem cells — such as the product of fertilization of an ovum and its progeny — are stem cells that have total potency, which means that they have the ability to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus. In contrast, human pluripotent stem cells, which are under discussion today, do not have total potency, and hence cannot form an entire organism under any known condition. But pluripotent stem cells can give rise to all of the different types of specialized cells in the body." (emphases added) [Back]

78  "For purposes of these Guidelines, 'human pluripotent stem cells' are cells that are self-replicating, are derived from human embryos or human fetal tissue, and are known to develop into cells and tissues of the three primary germ layers. ... NIH research funded under these Guidelines will involve human pluripotent stem cells derived 1) from human fetal tissue; or 2) from human embryos that are the result of in vitro fertilization, are in excess of clinical need, and have not reached the state at which the mesoderm is formed." (p. 7) (emphases added) [] [Back]

79  "Successful transfer of four– to eight–cell embryos ... to the uterus after thawing is now a common practice (Fugger et al., 1991) ..." (Moore and Persaud, p. 39); "After thawing four–cell embryos, some cells may not survive, leaving one–, two–, or three–cell embryos [in Prof. Dr. Mithhat Erenus, "Embryo Multiplication" ] "The oocytes are allowed to mature to the second meiotic metaphase and then fertilized with previously capacitated sperm, allowed to develop, and then inserted into the uterus at the 2– to 4–cell stage (or later)." (Larsen 1998, p. 18); "The embryos are usually allowed to develop to the two–to–eight–cell stage before they are considered ready to implant into the uterus. ... Embryos other than those used during the initial procedure are stored for future use if the first embryo transfer proves unsuccessful." (Carlson 1999, p. 35). [Back]

80  " ... (2) the fertilized egg, which has not yet divided, is now known as a zygote; (3) the egg begins to divide and is now known as an embryo; at this point each blastomere, or cell, within the embryo, is capable of developing into an identical embryo." [Geoffrey Sher, Virginia Davis, and Jean Stoess, In Vitro Fertilization: The A.R.T. of Making Babies (copyright 1998 by authors; information by contacting Facts On File, Inc., 11 Penn Plaza, New York, NY 10001), pp. 20]
"The embryo enters the uterine cavity after half a week, ... . Each cell (blastomere) is considered to be still totipotent (capable, on isolation, of forming a complete embryo), and separations of these early cells is believed to account for one–third of cases of monozygotic twinning." [ O'Rahilly and Muller (1994), p. 23]
Even NIH, in its recent stem cell research report, acknowledges that some of these "stem cells" are totipotent and can revert to whole embryos: "If these cells separate, genetically identical embryos result, the basis of identical twinning." ([National Institutes of Health, "Stem Cells: Scientific Progress and Future Research Directions; (Ruth Kirschstein and Lana R. Skirboll), Appendix A: Early Development, p. A–3) [] [Back]

81  For more details, please see my recent report, Analysis: Parts I and II: Stem Cells That Become Embryos: Implications for the NIH Guidelines on Stem cell Research, the NIH Stem cell Report, Informed Consent, and Patient Safety in Clinical Trials (July 22, 2001), written as a Fellow of the Linacre Institute, a Consultant for the Catholic Medical Association (USA), and a Consultant for the International Federation of Catholic Medical Associations (FIAMC), on issues relating to human embryology and human embryo research. See also my analyses for The University Faculty for Life: "University Faculty for Life: Submission of Concern to the Canadian CIHR Re the 'Human Stem Cell Research Recommendations 2001'"; written as UFL Board Member on behalf of UFL; submitted to Dr. Alan Bernstein, President, Canadian Institutes of Health Research Working Group on Stem Cell Research, Ottawa, Ontario, Canada, on June 3, 2001; "University Faculty for Life: Submission of Concern to the British House of Lords Re the 'Human Fertilisation and Embryology (Research Purposes) Regulations 2001'"; and, "University Faculty for Life: Letter of Concern to Sen. Brownback and Congressman Weldon Re the 'Human Cloning Bill 2001'".
See also: "Early mammalian embryogenesis is considered to be a highly regulative process. Regulation is the ability of an embryo or an organ primordium to produce a normal structure if parts have been removed or added. At the cellular level, it means that the fates of cells in a regulative system are not irretrievably fixed and that the cells can still respond to environmental cues. ... Of the experimental techniques used to demonstrate regulative properties of early embryos, the simplest is to separate the blastomeres of early cleavage–stage embryos and determine whether each one can give rise to an entire embryo. This method has been used to demonstrate that single blastomeres, from two– and sometimes four–cell embryos can form normal embryos, ... . ... Another means of demonstrating the regulative properties of early mammalian embryos is to dissociate mouse embryos into separate blastomeres and then to combine the blastomeres of two or three embryos. The combined blastomeres soon aggregate and reorganize to become a single large embryo, which then goes on to become a normal-appearing tetraparental or hexaparental mouse.... Blastomere removal and addition experiments have convincingly demonstrated the regulative nature (i.e., the strong tendency for the system to be restored to wholeness) of early mammalian embryos. Such knowledge is important in understanding the reason exposure of early human embryos to unfavorable environmental influences typically results in either death or a normal embryo." [Carlson (1999), pp. 44–49.] [Back]

82  "... Some types of twinning represent a natural experiment that demonstrates the highly regulative nature of early human embryos, ... Monozygotic twinning: If the splitting occurred during cleavage — for example, if the two blastomeres produced by the first cleavage division become separated — the monozygotic twin blastomeres will implant separately, like dizygotic twin blastomeres, and will not share fetal membranes. Alternatively, if the twins are formed by splitting of the inner cell mass within the blastocyst, they will occupy the same chorion but will be enclosed by separate amnions and will use separate placentae, each placenta developing around the connecting stalk of its respective embryo. Finally, if the twins are formed by splitting of a bilaminar germ disc, they will occupy the same amnion." [Larsen (1998), p. 325]. "Monozygotic twins and some triplets, on the other hand, are the product of one fertilized egg. They arise by the subdivision and splitting of a single embryo. Although monozygotic twins could ... arise by the splitting of a two–cell embryo, it is commonly accepted that most arise by the subdivision of the inner cell mass in a blastocyst. Because the majority of monozygotic twins are perfectly normal, the early human embryo can obviously be subdivided and each component regulated to form a normal embryo." [Carlson (1999), pp. 44-49]. [Back]

83  "The term 'clones' indicates genetic identity and so can describe genetically identical molecules (DNA clones), genetically identical cells or genetically identical organisms. Animal clones occur naturally as a result of sexual reproduction. For example, genetically identical twins are clones who happened to have received exactly the same set of genetic instructions from two donor individuals, a mother and a father. A form of animal cloning can also occur as a result of artificial manipulation to bring about a type of asexual reproduction. The genetic manipulation in this case uses nuclear transfer technology: a nucleus is removed from a donor cell then transplanted into an oocyte whose own nucleus has previously been removed. The resulting 'renucleated' oocyte can give rise to an individual who will carry the nuclear genome of only one donor individual, unlike genetically identical twins. The individual providing the donor nucleus and the individual that develops from the 'renucleated' oocyte are usually described as "clones", but it should be noted that they share only the same nuclear DNA; they do not share the same mitochondrial DNA, unlike genetically identical twins." [Tom Strachan and Andrew P. Read, Human Molecular Genetics 2 (New York: John Wiley & Sons, Inc, 1999), pp. 508–509] "Clone describes a large number of cells or molecules identical with a single ancestral cell or molecule." [Benjamin Lewin, Genes VII (New York: Oxford University Press, 2000), p. 955)] [Back]

84  "Some couples, however, may have only one or two embryos available for replacement. In such cases, patients may benefit from embryo multiplication, as discussed in the study by Massey and co-workers. ... In humans, removal of less than half of the cells from an embryo have been documented. No adverse effects were reported when an eighth to a quarter of the blastomeres were removed from an embryo on day 3 after insemination. ... Further evidence supporting the viability and growth of partial human embryos is provided by cryopreservation. After thawing four–cell embryos, some cells may not survive, leaving one–, two–, or three–cell embryos. These partial embryos survive and go to term, but at a lower rate than whole embryos." [in Prof. Dr. Mithhat Erenus, "Embryo Multiplication" micromanipulation/embryo_multiplication.htm ]
"Now, a new method of actually producing identical twins looms near. Called "blastomere separation" (the separation of a two– to eight–cell blastomere into two identical demi–embryos), it is potentially one method of helping infertile couples have children through in vitro fertilization (IVF)." [in The Twins Foundation, "New Ways to Produce Identical Twins — A Continuing Controversy" (]
"Because early embryonic cells are totipotent, the possibility of splitting or separating the blastomeres of early preimplantation embryos to increase the number of embryos that are available for IVF treatment of infertility is being discussed. Because embryo splitting could lead to two or more embryos with the same genome, the term "cloning" has been used to describe this practice. ... Splitting one embryo into two or more embryos could serve the needs of infertile couples in several ways. For couples who can produce only one or two embryos, splitting embryos could increase the number of embryos available for transfer in a single IVF cycle. Because the IVF pregnancy rate increases with the number of embryos transferred, it is thought that embryo splitting when only one or two embryos are produced may result in a pregnancy that would not otherwise have occurred. For couples who produce more than enough embryos for one cycle of transfer, splitting one or more embryos may provide sufficient embryos for subsequent transfers without having to go through another retrieval cycle, thus lessening the physical burdens and costs of IVF treatment for infertility. In addition, this technique may have application in preimplantation genetic diagnosis." [in American Society of Reproductive Medicine, "Embryo Splitting for Infertility Treatment" (]. [Back]

85  "Prenatal life is conveniently divided into two phases: the embryonic and the fetal. The embryonic period proper during which the vast majority of the named structures of the body appear, occupies the first 8 postovulatory weeks." [O'Rahilly and Müller (1994), p. 55]; "After the eighth week of pregnancy the period of organogenesis (embryonic period) is largely completed, and the fetal period begins." [Carlson (1999), p. 447]; "The first 8 weeks constitute the embryonic period. The remainder of gestation constitutes the fetal period." [Larsen (1998), p. 317]. [Back]

86  "Like all normal somatic (non–germ– cells), the primordial germ cells contain 23 pairs of chromosomes, or a total of 46." [Carlson (1999), p. 2]; "In a mitotic division, each germ cell produces two diploid progeny that are genetically equal." [Larsen (1998), p. 4].
"A subset of the diploid body cells constitute the germ line. These give rise to specialized diploid cells in the ovary and testis that can divide by meiosis to produce haploid gametes (sperm and egg). ... The other cells of the body, apart form the germline, are known as somatic cells ... most somatic cells are diploid ...". [Tom Strachan and Andrew Read, Human Molecular Genetics: Second Edition (New York: Wiley–Liss, 1999), p. 28].
"Gametogenesis is the production of germ cells (gametes), i.e., spermatozoa and oocytes. These cells are produced in the gonads, i.e., the testes and ovaries respectively. The gametes are believed to arise by successive divisions from a distinct line of cells (the germ plasm), and the cells that are not directly concerned with gametogenesis are termed somatic. ... The reduction of chromosomal number from 46 (the diploid number) to 23 (the haploid number) is accomplished by a cellular division termed meiosis. ... Primordial germ cells ... are difficult to recognize in very young human embryos. Claims for them have been made as early as in the blastocyst, and they are believed to be segregated at latest by 2 weeks and possibly much earlier." [O'Rahilly and Muller (1994), pp. 13–14].
"Meiosis is a special type of cell division that involves two meiotic cell divisions; it takes place in germ cells only. Diploid germ cells give rise to haploid gametes (sperms and oocytes) [after puberty and beyond, that is]. [Moore and Persaud (1998), p. 18]. [Back]

87  "From the ethical point of view, an important consideration is to what extent technologies developed in an attempt to engineer the human germline could subsequently be used not to treat disease but in genetic enhancement. There are powerful arguments as to why germline gene therapy is pointless. There are serious concerns, therefore, that a hidden motive for germline gene therapy is to enable research to be done on germline manipulation with the ultimate aim of germline–based genetic enhancement. The latter could result in positive eugenics programs, whereby planned genetic modification of the germline could involve artificial selection for genes that are thought to confer advantageous traits." [Strachan and Read (1999), pp. 539-541].
The use of germ–line gene "therapy" by U.S. scientists has recently been published, producing genetically altered human infants. See, Dr. David Whitehouse, "Genetically altered babies born: Mitochondria contain genes outside the cell's nucleus", BBC News Online, [Back]

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